DeWITT, N.Y. — Upstate Medical University on Monday, July 7 broke ground on a new, 109,000-square-foot clinical pathology laboratory facility, known as the Upstate Pathology Institute.
It’s located at 6624 Fly Road in the town of DeWitt, adjacent to Upstate Bone and Joint, home of Upstate Orthopedics.
The project will consolidate and modernize Upstate’s pathology department, “positioning it for future growth, improved efficiency, and expanded regional service that will be facilitated by drone operations,” per the Upstate announcement.
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The upcoming Institute will centralize Upstate’s “sprawling” pathology service into one location when the building opens in spring 2027.
Upstate’s pathology services currently operate across 55,000 square feet in five separate floors in three different buildings on Upstate’s downtown Syracuse campus. It processed more than 3.2 million specimens in fiscal year 2024, the medical school and health system noted.
The Upstate Pathology Institute will accommodate 178 of the pathology department’s current 228 employees, while 50 staff members will remain at the downtown campus to support hospital-based lab needs. Additionally, the Fly Road location will have “substantial” job growth, beginning with the addition of 25 new jobs in its first year of operation. Employment projections estimate another 10 new jobs will be added in each of the following two years, resulting in a total of 45 new positions and bringing the Fly Road lab’s workforce to 223 by year three.
Representatives of Upstate Pathology Lab Ownership, LLC; the building’s owners Dr. A. John Merola and John Murphy; and various community leaders joined Upstate officials for the groundbreaking event.
The new facility “moves Upstate Pathology well into the future,” Dr. Mantosh Dewan, president of Upstate Medical University, said in the announcement.
“This new Institute will transform the practice of pathology and help us meet the increasing demand for our services with greater efficiency and set a standard for laboratory science,” Dewan said. “This expansion enhances our academic mission, supports patient care across the region, and reinforces Upstate’s commitment to being a leader in innovative, accessible, and high-quality healthcare.”
The new three-story building will bring together services that include the core laboratory, microbiology lab, histology, immunohistochemistry (IHC), cytology, electron microscopy, bone marrow, hematopathology, cytogenetics, flow cytometry, molecular lab, bioinformatics & digital pathology, Upstate said.
The building will also include teaching, conference, and employee-support spaces, as well as areas for drone and courier-specimen transport.

